Recent efforts to prevent post-partum haemorrhage (PPH) in low-income countries have focusedon providing women with access to oral misoprostol during home birth. The WHO recommendsusing lay health workers (LHWs) to administer misoprostol in settings where skilled birth attend-ants are not available. This review synthesizes current knowledge about the barriers and facilitatorsaffecting implementation of advance community distribution of misoprostol to prevent PPH, wheremisoprostol may be self-administered or administered by an LHW.We searched for and summarized available empirical evidence, and collected primary data fromprogramme stakeholders about their experiences of programme implementation.We present key outcomes and features of advanced distribution programmes that are in operationor have been piloted globally. We categorized factors inﬂuencing implementation into those thatoperate at the health system level, factors related to the community and policy context and thosefactors more closely connected to the end user.Debates around advance distribution have centred on the potential risks and beneﬁts of makingmisoprostol available to pregnant women and community members during pregnancy for admin-istration in the home. However, the risks of advance distribution appear manageable and the bene-ﬁts of self-administration, especially for women who have little chance of expert care for PPH, areconsiderable.